Anxiety, Depression & Mood Disorders
About This Condition
Anxiety disorders and depression are the two most prevalent mental health conditions in the United States, affecting over 40 million and 21 million Americans respectively. Both are heterogeneous in their biology: while the serotonin-deficit model has dominated psychiatry for decades, the evidence now clearly supports multiple overlapping pathophysiologies — HPA axis dysregulation (chronic cortisol elevation), neuroinflammation, mitochondrial dysfunction, gut-brain axis disruption (the "second brain"), thyroid dysfunction, nutritional deficiencies (B12, folate, vitamin D, zinc, magnesium, omega-3), hormonal imbalance, and trauma-driven limbic sensitization. Treating all of these with a single SSRI is, by definition, inadequate for many patients.
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